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Conolidine’s analgesic outcomes stem from its interaction with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors during the central nervous program, conolidine modulates alternate molecular targets. A Science Innovations study discovered that conolidine interacts With all the atypical chemokine receptor ACKR3/CXCR7, whic… Read More

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Elucidating the specific pharmacological mechanism of motion (MOA) of naturally transpiring compounds could be difficult. Although Tarselli et al. (60) made the primary de novo artificial pathway to conolidine and showcased that this naturally transpiring compound correctly suppresses responses to equally chemically induced and inflammation-derived… Read More

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